Both the Yukon and Grand Cherokee L have child safety locks to prevent children from opening the rear doors. The Yukon has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Grand Cherokee L’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Yukon has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The Grand Cherokee L doesn’t offer front seat center airbags.
To deliver safety and visibility under dusty conditions the GMC Yukon’s backup monitor has a standard rear washer to keep the view clear. A camera washer system costs extra on the Jeep Grand Cherokee L.
Both the Yukon and Grand Cherokee L have rear cross-traffic warning, but the Yukon has Rear Cross Traffic Braking (automatically applies the brakes) to better prevent a collision when backing near traffic. The Grand Cherokee L’s Rear Cross Path Detection doesn’t automatically brake.
Both the Yukon and the Grand Cherokee L have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, available all wheel drive, night vision systems and driver alert monitors.
The GMC Yukon weighs 534 to 1420 pounds more than the Jeep Grand Cherokee L. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

